A Look at Gulliver’s Travels

The masterpiece of fantasy with unforgettable little people, giant people, flying islands, and talking horses, Jonathan Swift creates a new popular genre of realistic novel which is to present plausible details as if they were literally true through the book Gulliver's Travels. Swift first published the book in London with the title Travels into Several Remote Nations of the World with the alias Lemuel Gulliver. Only a few knew that the real author was Dr. Swift, the distinguished Dean of the Anglican St. Patrick's Cathedral in Dublin. Many people including, Samuel Johnson, remember the novel as a as â€Å"a production so new and strange that it filled the reader with a mingled emotion of merriment and amazement. † Swift arises emotions by comparing and contrasting the church and state in the islands of Lilliput and Brobdingnag. Lilliputians, the small people, are used to bring about state control and religious minimization. They had a strict and concise government often portraying life as complicated and complex. The inhabitants of Lilliput do not raise their children but instead send them to distant schools near the capital city where the children are raised by teachers and other members of the school system. Parents can interact with their children only twice a year creating a barrier between the relationship between the two generations. However, children of the poor are able to stay at home and share the workload with their parents. The separation between the rich and the poor class depicts the governments view on society and how it should be run. The governing system of Lilliput attempts to portray equalization and equal opportunities, but, in context of terms and actions one is able to witness the separating factors of class separation and distinction. The power is mainly held in the hands of the emperor who is able to mandate decrees and create laws, although the approval of the people and government officials is also needed. An example would be when the â€Å"emperors father published an edict, commanding all his subjects, upon great penalties, to break the smaller end of their eggs. (40) The government of the Lilliputians is in direct control of the people. They are able to make decisions and regarding every aspect and nature of the Lilliputians- both socially and politically while the church plays no role at all. The mention of a religious organization or association is never mentioned in the novel and the audience is led to assume that their was no major role if their was a church. The state plays a dominating role in the lives of the Lilliputians making it difficult to let any other institution come in the way, including a religious one. Enabling a religious or church association would put the Lilliputian government at a disadvantage, letting the people have an alternative voice to listen too. In the island of the Borabdingnagians there is a dominant role of the church and a simple and broad role of the government, a contrast to the Lilliputians. The people of Borabdingnag attend Sabbath on Wednesdays displaying their dedication and devotion to the church. The respect and responsibility of the people to attend Sabbath enable the audience to understand the major role of the Church in the lives of the citizens. Their religious aspect and beliefs shape their morals and in effect play a major role in every aspect of their lives. Unlike the citizens of Lilliput the Church is the dominating organization in which the political government is in accordance with. The government is described as being simple and broad a collaboration of â€Å"narrow principles and short views† (135) . The simplicity of the government enables the Church to play a more dominant role and influence the lives of the Borabdingnagians.

Modern effect towards Shakepears Romeo Essay

I will produce the play in Las Vegas so I can create a modern effect towards Shakepears Romeo & Juliet. I’ve chosen to produce Act 1 Scene 1, because it will show the tension between the two families already before the film unfolds. The scene has lots of action and there’s a variety of things happening. The Montague’s own a casino called Gamblers Paradise. The Capulets are also in the gambling business; their casino is called Snake Eyes. There is a massive rivalry between them because of the substantial amount of money involved and the intense competition. Tybalt wants to shut the Montague’s business for good. The servants are employees of their families casino’s, and the Prince is the head of the F.B.I. Leading up to the scene  There will be a short clip showing how the feud between the two families began. The Montague’s were situated there first. Their income was soaring through the roof, until the Capulets arrived and opened their newly built casino adjacent to them. The Montague’s income plummeted dramatically and they were infuriated about it. So they began their plan to make the Capulets lives hell.When the scene opens, the two Capulet servants walk out of the casino joking and laughing. The camera will face them from the Montague’s casino and will zoom in slowly. The servants walk down the street towards a cafà ¯Ã‚ ¿Ã‚ ½ they always go to every lunch break. As they are walking, the camera has a close up on Sampson when he is talking and when Gregory is talking; the camera switches to him. When they are near the cafà ¯Ã‚ ¿Ã‚ ½, the camera goes into the cafà ¯Ã‚ ¿Ã‚ ½, moving in a circular movement. Then it stops on Abraham, a Montague servant. Abraham is drinking a cup of coffee. The camera is facing the door of the cafà ¯Ã‚ ¿Ã‚ ½ from inside, waiting for the Capulet’s to enter. Next, the door swings open and the Capulet’s look around and spot Abraham. The camera switches to Abraham. He sees them in the corner of his eye. He gulps down the last mouth full of coffee and walks over to the counter. The camera moves behind the counter. He pays for the coffee and turns to the Capulet’s. Gregory says, â€Å"I will frown as I pass by, and let them take it as they list†.  Sampson replies â€Å"Nay, as there. I will bite my thumb at him, which is disgrace to him if he bear it.†Ã‚  Ã¢â‚¬Å"Do you bite your thumb at us sir?† says Abraham in a deep shaky voice.  Abraham walks over to them. Then suddenly he lashes out with a punch to Gregory. The camera moves to the right and zooms in on the action. The fight is interrupted by the appearance of Benvolio. Benvolio enters and shouts, â€Å"Part, fools! Put up your hands; you know not what you do.†Ã‚  Tybalt stampedes through the door with attitude and says, â€Å"What art thou drawn among these heartless hinds? Turn thee, Benvolio, look upon thy death.†Ã‚  Benvolio replies, â€Å"I do but keep the peace. Put up thy hand, or it to part these men with me.†Ã‚  Ã¢â‚¬Å"What, drawn and talk of peace? I hate the word, as I hate hell, all Montague’s, and thee. Have at thee, coward.† Tybalt replies with anger. Then Abraham pulls out a gun, he is extremely nervous at this moment in time. Sweat runs slowly down his forehead. Sampson kicks the gun out of Abraham’s clench fist. Gregory does a backward roundhouse kick to the face of Abraham, who is stunned. The camera switches behind Abraham and zooms out a bit. He flies through the air and crashes onto a table with a bone-breaking thump. The camera is now at a bird’s eye view of the crisis. Abraham is bleeding from several places and he is unconscious. Blood is trickling from the edge of the table. Citizens gather round shouting, â€Å"Down with the Capulets, down with the Montague’s.†Ã‚  The camera is behind the citizens at head level. Immediately Montague and Capulet appear on the scene. Old Capulet calls for shotgun. For a moment the two wives try to restrain their husbands, but their efforts are unnecessary. The F.B.I squad pulls up outside the cafà ¯Ã‚ ¿Ã‚ ½. â€Å"The Worlds Greatest† by R.Kelly is playing in the background. As the prince steps out of his Lexus, the camera has a close up on his face. Prince Escales says loudly through a tannoy, â€Å"Old Capulet and Montague have disturbed our streets once again. If you ever disturb our streets again, your lives shall pay the forfeit of the peace. For this time all the rest depart away: You Capulet, shall go along with me, and Montague I will come for you this afternoon, to know our further pleasure in this case, to old Free-town, our common judgement-place. Once more, on pain of death, all men depart.† How the scene develops  With the departure of the Prince, the mood changes.  Lady Montague asks â€Å"O where is Romeo? I saw him to day? I am glad he was not at this fray†.  Lady Montague spots Romeo in the distance. The camera zooms in on lady Montague. Benvolio describes the behaviour of his infatuated friend. Romeo gets up before dawn, walking alone in the woods and weeping as the sunrises. The camera follows him from behind, capturing the beautiful sky. He hurries home and locks himself in his room and shuts out the daylight. At this point, â€Å"Hero† by Enrique is playing. These are symptoms of unrequited love, although neither Benvolio nor Romeo’s parents appear to recognise this. How does your treatment of the play show its relevance to people today?  Romeo and Juliet relate very well to today. For example, each family wants revenge on the other. This can relate to the families who were affect by Myra Hindley. She was a sick twisted individual who killed children. Every one wanted her to die and suffer for what she did. All families have disagreements, arguments, and fights but that’s part of life every thing will eventually sort it self-out. So really what happens in Romeo and Juliet isn’t unusual.

Valuation of two England football clubs Essay Example | Topics and Well Written Essays - 2250 words

Valuation of two England football clubs - Essay Example Consequently, this paper undertakes a valuation review of two leading teams in the English premier league namely the Southampton Football Club and Portsmouth Football Club. This has been done by reviewing the financial performance of the two clubs over the last five years to depict the current and future possible value of investing in the two different clubs. Southampton Football Club Southampton football club is one of the oldest football organizations in the English premier league since its formation in 1885. The club has been associated with the church since its formation that has earned it the saint’s nickname (Southampton.com, 2013). The performance of the team in the past has been relatively poor since it was relegated on 15 May 2005 from the premier league competitions. However, the club has been able to return to the premier league tournaments in the latest season. Furthermore, the club has been able to win the FA cup title in 1976 and second position in First Division tournament in 1984 (Southampton.com, 2013). Accordingly, the performance of the club in the past has been relatively poor compared to other clubs in the English major tournaments. Currently, the team is ranked at position 33 in the English premier league tournament after it was promoted last season. ... This has seen the financial returns of the club been relatively stable and attractive. Indeed, the club is one of the highest owned clubs by the fans due to its performance over the years. In addition, the club has been able to attract a number of the best players in the English tournaments. Currently, the club is at position 24 in the English premier league (Portsmouth.com, 2013). Financial Ratios valuation To demonstrate the financial valuation of the two organizations, a five years financial ratios computation has been undertaken. In addition, financial valuations of the two clubs have been undertaken by using the financial results of 2012. This is as demonstrated by the computations below. Financial Ratio 2012 2011 2010 2009 2008 Liquidity ratios Current ratio = (current assets/ current liabilities) (Stickney, 2010) Southampton Football Club = (20,07700/ 37,306,000) = 0.54 Portsmouth Football Club = (3133294/ 361,098) = 8.68 Southampton Football Club = (14,694,000/ 25,650,000) = 0.57 Portsmouth Football Club = (6046092/ 339482) = 17.81 Southampton Football Club = (15472/ 7990 = 1.9 Portsmouth Football Club = (2480024/ 314692) = 7.88 Southampton Football Club = (1359.2/ 620) = 2.2 Portsmouth Football Club = (1974021/ 239,815) = 8.23 Southampton Football Club = (1362.0/ 614.8) = 2.22 Portsmouth Football Club = (1471235/ 235240) = 6.25 Quick ratio = (quick assets/ current liabilities) Quick assets = (current assets – inventories) Southampton Football Club = [(20,077,00 – 2,806,000)/ 37,306,000] = 0.46 Portsmouth Football Club = (3,133,294 – 32,541)/ 361,098) = 8.5 Southampton Football Club = [(14,694,000 – 1,902,000)/ 25,650,000] = 0.45 Portsmouth Football Club = (2207669 – 30,282)/

Financial Aspects of Recreation and Sport Essay Example | Topics and Well Written Essays - 500 words

Financial Aspects of Recreation and Sport - Essay Example One of such key issues in the address was on trade policy. In his address to Americans President, Obama showed the need to protect business and citizens to have a fair share in foreign trade. In order to do that the president requested the need for parties to provide him trade promotion authority. This would help Americans be sure of the world economic market that Obama projected to have 25% customer base. He added that this would be with new trade agreements or deals from Europe to Asia that are free and fair. Basing on the context of recreational Industry, the address provides for many potential gains as individual firms can expand abroad and in turn come and invest even more within the borders of United States. The proposal by the president is essential and will impact the industry in the long run as it aims to open even larger markets in regions that United States previously ignored. There are a lot of advantage in recreation industry that accrue from improved trade links between United and other regions of the world. The industry is dynamic and requires a lot of within and out of border investors. Investment in recreation and sports industry has been a challenge and through more open links there is a possibility of a boost in investment. Growth is also expected through innovations and research. The second issue was the president intention to protect a free and open Internet, and extend its accessibility to every classroom, and far to every community and assist folks build the quickest networks so that the future will be of digital innovators and successful entrepreneurs have the platform to continue reshaping the world. The address used example of China that has been making great strides in making global treaties at the expense of United States. Critically analyzing the potential gains from this agenda, it can be deduced that the initiative will help grow recreational industry. Accessibility of free and open internet provides an opportunity for

Physiology and Function Essay Example | Topics and Well Written Essays - 250 words - 2

Physiology and Function - Essay Example Thermoregulation effects of feeding influence the  BMR, which is the amount of calories needed for absorption, transport, digestion, and storing the food consumed. The thermoregulation effects of activity are the rate of burning calories in a human being by exercising and normal movements (Faires, 2011). The body obtains these nutrients from proteins like meat, eggs, and beans are they are essential in a human being. In this case, dietary allocations of essential ammino acids increase muscle protein synthesis (Hulmi, Lockwood, & Stout, 2010). Metabolism refers to the physical and chemical processes that take place in the cells of a living organism in order to sustain the life of the organism. These processes encourage growth, reproduction and allow living organisms to maintain their structures and respond to their environment. These processes require nutrients absorption and production of energy in order to thermo regulate the body (Rose, 1999). Catabolism is a complex process where substances are broken down into simple substances by living cells (de Bolster, 1997). The process liberates energy that is used for work, heat production and energy storage from body nutrients during metabolic body processes. It produces carbon dioxide water and

Motivating employees Essay Example | Topics and Well Written Essays - 1000 words

Motivating employees - Essay Example The management of any organization will tend to select some of the theories that connect appropriately with the long-term and short-term strategies. In this case, the theories of motivation will always integrate within the general mission and goals of any organization. The goal-theory, self-determination theory, and theory X and theory Y are some of the commonly applied theories in the pursuit of desired objectives (Hoffmann, 2007). The nature of the organization determines the kind of theory applied in accordance with the strategies and frameworks of the organization. In this regard, motivation theories help to condition workers towards the attainment of the organization goals. The theories also help in preparing the workers for personal fulfillment in terms of career growth and individual development. Some organization operate policies that project uniform achievement between the workers and the company. Such a perspective connects with the concept of total quality management. As such, it becomes necessary to consider the fact that a range of issues that connect with the processes of motivation will also involve the determination of goals and aspirations of the various. Most of the theories of motivation are tailored towards the process of controlling behavior. The acknowledgement of human nature and the power of the environment, incentives, threats, to control outcomes in organizations usually depend on the type and impact of the theory. For instance, a firm that seeks to develop the human capital of its work force may engage self-determination theory.... Self-determination theory often enables the creation of positive attitudes in the organization by encouraging workers to strive towards the attainment of the specific goals that relate to the various processes that align with the combined objectives of the company. On this matter, the determination of the levels of efficiency and productivity of a worker are regulated by the nature of the environment. A range of processes often involves the creation of systems and structures that aid the processes of performance of the workers. The self-determination theory offers employ the opportunity and support to explore the limits of their potentials and talents. Applying this theory within an organization may involve setting of targets and limits for the workers in order to assess their capabilities and capacities to achieve set goals. In the end, both the company and the workers benefit in a seamless manner that determines the degree of balance between effort and rewards. Psychological explan ations of this theory hold that humans will often respond positively to challenges that come with some levels of reward. Within an organizational set-up, there remains a range of factors that connect appropriately with the various issues related to personnel development of the workers. Rewards such as promotions and salary increments have often been used alongside the self-determination theory to align the efforts and dedication of workers towards the attainment of specific goals. Reviews of the efficacy of the goal theory show that some of the processes of motivation will tend to merge with the manner in which goals determine the processes of an organization. In normative practice, goal setting entails the determination of a range of available

Law and management Essay Example | Topics and Well Written Essays - 2000 words - 1

Law and management - Essay Example IMO purpose is established in the ISM Code to reduce damages and accidents during shipping and voyage. Especially in operations of the ship. This code promotes cleaner and safer ships (Anderson, 2003, pg 23). The MV ‘Shields Happiness’ ship requires proper safety management to ensure competence by the crew in the ship. In this scenario between the Hall and South Shields, pollution was caused during voyage because the drip trays had not been cleared of oil and the oil later overflowed in the main deck. If the crewmembers had applied the safety management culture, they would constantly think about improvement and safety of the ship. They would have improved the deep trays by clearing the oil voyage. In addition, the Third Mate would constantly be thinking of safety and would have rechecked whether his instructions were followed. With this safety culture it places a duty on everyone on board to be constantly thinking about the safety of the ship, therefore another crewmember would have noted the discrepancy and cleared the oil on the drip trays, and this would have avoided overflow into the main deck that polluted the sea. Application of the safer culture management method would support and encourage safety in shipping. This method of management is successful if certain factors like commitment, belief and values are instilled to the shipping crewmembers. Such values of safety, if instilled in the maritime personnel, would create a positive impact (Anderson, 2003, pg 44). The second scenario shows that the tanks were not correctly inserted, and the required oxygen was not at the required level that caused a 12-hour delay and this increased costs. To improve the efficiency and performances of the ship by the ship-owner, the method to incorporate would be the organizational culture. This type of culture applies where there is a group of people from and can form their culture. There are two perspectives on it that

Personal Resourcing and Development Essay Example | Topics and Well Written Essays - 1500 words

Personal Resourcing and Development - Essay Example After the implementation of active workplace programme at Ginsters, a survey highlighted that the workers in the organisation engage with the company and assume pride in doing their work. This is an indication of increased motivation in comparison to the prior years. Despite the fact that the employees of Ginsters stood and worked for long hours, a fitness test conducted by the Caradon Council found them to be unfit (Hudson, 2010). This made the company employ a fitness coordinator on fulltime basis and purchased a gym in an existing building. This was an incentive or reward to the workers. The manager of Ginsters acknowledged that the workers had been convinced to participate in the different activities within the organization. At Ginsters, the motivational theory that can be applied to the situation of employees is the expectancy theory. According to this theory, the employees perform their work in a hard and smart way whenever they believe that their additional efforts would resul t into rewards that are valuable (Pinder, 2008). This is evidenced at Ginsters when a gym is introduced in the existing building of the organisation to offer exercises to the workers. The expectancy theory of motivation highlights that increased output would be given by the equation; Motivational or effort force = Expectancy (Instrumentality x Valence) (Pinder, 2008). In this case effort force implies the force expended by the employees in achieving the performance that is desired. Expectancy is the belief that any force or effort would lead to a required performance level (Mitchell, 2003). On the other hand, instrumentality implies the thought that the needed performance will lead to an outcome that is desired and... From this paper it is clear that  Ginsters company is a winner of the World Leisure 2008 innovation award and the company’s   active workplace employee programme wellness has experienced significant results.  This essay stresses that  the company failed to have a firm a stand on its employer. Despite the fact that this company provides a significant amount of career opportunity for individuals, the company experiences various challenges. About 18 % of the 450-workforce strongholds were obtained from   individuals with minority backgrounds. These people were constantly resisting the chances to be integrated   into the company team. The day and night shifts did not mix and the different production areas mistrusted each other. An annual survey study established that the morale of the workers was low. After the implementation of active workplace programme at Ginsters, a survey highlighted that the workers in the organisation engage with the company and assume pride in doing their work. This is an indication of increased motivation in comparison to the prior years. Despite the fact that the employees of Ginsters stood and worked for long hours, a fitness test conducted by the Caradon Council found them to be unfit.  Instrumentality implies the thought that the needed performance will lead to an outcome that is desired and valence is the employees outcome value. The active workplace programme implementation at Ginsters, was an aspect of expectancy theory.

Sauce - Barbecue Essay Example for Free

Sauce Barbecue Essay Choose the most appropriate answer for each question.Shade your choice on the Objective Answer Sheet. 1. Egg whites will whip up into a better foam if a) they are at room temperature b) they are well chilled c) they have small amount of baking soda added to them d) they have small amount of oil added to them 2. Which of the following combination is incorrect ? a) Cinnamon-bank b) Cumin-seed c) Marjoram-root d) Clove-bud 3. Potato is a a) starch b) vegetables c) both a and b d) neither a nor b 4. Which of the following terms is associated with broiling? a) low heat b) tender food items c) slow d) all of the above 5. Deglazing takes place after a) broiling b) grilling c) deep-frying d) sautà ©ing 6. Which of the following might produce a cloudy stock? a) Using the fresh bone b) Covering the pot c) Skimming frequently d) Simmering gently 7. ____________are made from forcemeats of poultry or game wrapped in the skin of the bird and poached in an appropriate stock. a) Quenelles b) Pate c) Terrine d) Gelatine 8. When making mayonnaise,it is essential to ____________. a) Beat the egg yolks well in a bowl b) Have all the ingredients as cold as possible c) Use highly flavoured ingredients d) Add the boil all at once 9. The_________ of a slice of meat determines its cooking time. a) thickness b) grade c) weight d) age 10. Which of the following thick soups are most likely to contain seafood? a) cream soup b) purees c) bisque d) potages 11. Vegetables are least likely to be__________ . a) poached b) braised c) boiled d) deep fried 12. _________ can protect a roast from drying while cooking. a) cooking it fat side up b) barding c) larding d) all of the above 13. To make a white roux with 250gm of butter,you will need a) 500 ml cornstarch b) 125 gm flour c) 250 ml flour d) 250 gm flour e) 14. Which of the following is not a function of fats in baked goods? a) to give firmness to the structure b) to add moistness c) to give crust color d) to increase product qualities 15. Artichokes and asparagus are considered as a) cabbage family b) shoots c) leafy vegetables d) onion family 16. A liaison is added to a sauce __________. a) at any time during cooking b) at the beginning of cooking c) just before the sauce is reduced d) at the end of cooking 17. Which of the following is least likely to be found in a sachet? a) bay leaf b) garlic c) peppercorn d) dried thyme 18. A prawn is a ___________. a) large shrimp b) green shrimp c) crustacean d) both a and c 19. Which of the following would generally not to be served with fish a) caper sauce b) lemon butter sauce c) demi glace d) tartare sauce 20. Which is the best answer that describes the effects of heat to food composition i. Proteins coagulate ii. Sugar caramelize iii. Water evaporates iv. Fat solidify v. Starches gelatinized a) i only b) i and ii only c) i,ii,iii and v d) all the above PART B TRUE AND FALSE Shade the letter ‘T’ if the statement is True and ‘F’ if the statement is False on the True/False Answer Sheet. 1. Bones that are exposed to air during cooking will turn dark and this will discolour the stock. 2. Broth and bouillon refer to simple,clear soups without solid ingredients. 3. Low temperature produces the best cooked eggs. 4. Yeast is a non living microscopic plant. 5. A heavy whipping cream has a fat content between 36%-40%. 6. In standard breading procedure moist items should be held longer before to extract moisture. 7. Red snapper is a type of fresh water fish. 8. Hard cheeses,such as parmesan can be grated easily. 9. A squab is a young pigeon with light and tender meat. 10. Marbling separates muscle fibers making them easier to chew. 11. The market form of whole fish usually has had the viscera removed. 12. All kind of scraps can be used in stocks at all time with no exception. 13. Rigor mortises is the stiffness in an animals muscles,due to chemical changes in the flesh. 14. The compound that colors red vegetables red is carotenoids. 15. The neck and back of a chicken is the best bones for stock making. 16. A classical Tomato Sauce is made with roux. 17. In order to obtain the maximum volume from whipped eggs white,all traces of fat must be eliminated. 18. The term dressing also refers to â€Å"food stuff† that is baked separately. 19. The chef cold larder supervises the cold meat department and breading of meats,fish and seafood. 20. Whole spices take shorter time to release its flavour. PART D SHORT ESSAY Answer ALL questions. QUESTION 1 Explain why sauces that are finished with butter must be served immediately. The sauce should then be served immediately if it is allowed to stand,the butter may separate. QUESTION 2 Name and explain the three(3) ingredients that made up a sauce. -A liquid ,which is the body of the sauce. -A thickening agent -An additional seasoning and flavouring ingredients. QUESTION 3 Names the five(5) important parts of meat tenderloin and briefly describe the characteristics of the meat. 1-chateaubriand 2-fillets 3-tornedos 4-fillet migaou 5-goulash QUESTION 4 Give the definitions of herbs and spices.Name four(4) spices and four(4) herbs that are commonly used in cookery. Herbs are the leaves of certain plants used in flavouring.The examples of herbs are thymes,bay leaves,rosemary and basil. Spices are any part of plant,other than that,the leaves used in flavouring.The examples of spices are celery seeds,cumin seeds,caraway seeds and cloves. QUESTION 5 List the four(4) basic ingredients of clear meat. i. Lean ground meat ii. Egg white iii. Mirepoix iv. Acid ingredients QUESTION 6 What is different between marbling and barding? Marbling is fat deposited within muscle tissue while barding is tying slices of fat over the surface of meat to protect them while roasting.

Mission & Vision Essay Example for Free

Mission Vision Essay The article speaks about how a mission should be written, so it will provide a clearer and well defined purpose. It’s explained the advantages and limitations of having it. It also explore whether a standalone statement or a broader model should be a better mission statement. This is followed by proposing a new definition of a mission, demonstrating how it is rooted in good practice, and presenting its benefits and limitations. Some context of practical implication discussed as well. Findings The paper initially shows the inconsistent use of the concept of mission in the expanded list approach. It then proceeds to show similar inconsistencies in three of the most respected models of guiding statements in the literature. Vision Framework (Collins and Porras (1991, 1995, 1996, and 1997) Ashridge Mission Model (Campbell and Yeung (1991)) Model of organizational vision –Liptons Model (Lipton’s (1996, 2003)) Mission Statements Approaches Check List Type: The article says that to get a well-defined mission statement, it has to have the checklist-type approach. Research shows that many times companies are only setting a single line of mission statement which does not constitute all the items in the checklist which makes it a poor mission statement. This is where suggestions are being made to the organizations to redefine the mission statement  by David and David (2003), They suggest the following comprehensive list of nine components that an effective mission statement should include: Customers (the target market) Products/services (offerings and value provided to customers) Geographic markets (where the firm seeks customers) Technology (the technology used to produce and market products) Concern for survival/growth/profits (the firm’s concern for financial soundness) Philosophy (the firm’s values, ethics, beliefs) Public image (contributions the firm makes to communities) Employees (the importance of managers and employees); Distinctive competence (how the firm is different or better than competitors). Compilation Logic: Variously referred to as statements of purpose, values statement, goals and strategies, corporate creed, corporate philosophy, and so on. (Leuthesser and Kohli (1997,). A mission statement is a clear definition of the mission and purpose of the organization, it may be referred to as the organization creed statement, statement of purpose, statement of general principles, statement of corporate intent or vision statement. † (Strong (1997, p. 269)) Strategic Intent: â€Å"Strategic intent captures the essence of winning† (Hamel and Prahalad, 1989, p. 64). An effective mission statement basically answers one question: How do we intend to win in this business? † Welch and Welch (2005, p. 14). Brief on the Model Vision Framework: In vision framework, a well-conceived vision consist of 2 major parts. Those are core ideology and envisioned future. The core ideology speaks about the purpose of the organization. It consists of explaining the character of the organization, what it stands for and why it exists. The 2 parts of core ideology are core values and core purpose. Core values are the principals of the organization and core purpose is the fundamental reason of the organization existence. The envisioned future is what the organization would like to achieve. Ahihridge model: In Ashridge model, the mission statement should consist not only the purpose but also the strategy, values and standards of behavior. The purpose in this context reflects as to who the organization is on business for. The strategy part speaks about the business logic on saying which business brings the competitive advantage while the values speak of the emotional and moral logics which eventually motivate the employees. The standards of behavior will convert the strategy and values into policies and guidelines. Liptons Model: Lipton’s model speaks of 3 components. Those are mission, strategy and culture. The mission specifies the fundamental and unique purpose of the business. The strategy is about how the mission can be achieved while obtaining the competitive advantage of the business. The culture is the part which describes the values, standards of behavior and leadership style of the organization Differences of 3 Model The â€Å"Ashridge† model emphasizes the importance of a â€Å"sense of mission† and Lipton talks about a â€Å"sense of vision. In both models can see purpose, strategy, values, and standards of behaviors. However the vision model comprises of vision and mission elaborated both other 2 models. The contents of those elements, however, are not always the same. Proposed Definition The proposed definition of mission statement should consist of 3 things. Those are, commitment to reflect authenticity of the mission, a significant value which is exciting and inspiring and a worthy cause for the members of the organization to embrace on. This new definition aims to provide benefits are individual and organization level. Two benefits can be derived and those are to create a clear focus for the employees and it helps organizations to make strategic decision in regards to resources which help the success of the business. Strength Drawback Analysis The variety of organizations’ mission statements is so wide that no single definition can possibly be exhaustive. There are authentic and fabricated mission statements, and not all existing varieties are necessarily authentic. This definition, by design, excludes all those varieties of mission statements that are not authentic, i. e.  that imply no particular choice. The proposed definition reverses the logic of compilation and synthesis in favor of a more focused approach. Evidently, a definition built on choice can never be exhaustive. Limitation Direction for future Research The paper, however, focusses mainly on content and does not thoroughly address the process of developing a mission and how this process relates to and influences the mission ’s content. This is a fruitful research opportunity. Observation Mission statement framework should include some components to measure the organizational outcomes.

Analysis of Causes of UAE Economic Downfall

Analysis of Causes of UAE Economic Downfall Introduction and Business reasons: The global liquidity crunch has affected most of the countries and among the highly affected countries is United Arab Emirates which was one among the growing business hubs in the world with its massive development and acceptance of different culture and business. Dubai known as the economic capital of U.A.E was badly affected by the recession. Consequently, huge fortunes have been wiped out due to Dubais current economic crisis exposing the risk of doing business in the Gulf. The expansion of Dubai was very ambitious but improbable. A $64 billion project that was initially planned at 107 square miles for a development that was to be the worlds largest collection of theme parks, shops, residences, and hotels called the Dubai Land.  For now all these remain a fantasy which is the cause of the economic downturn. WILSON, Z (2009) As a consequence to that, various other projects like an underwater hotel, a Tiger Woods golf course, a residential community set among full-scale replicas of the Seven Wonders of the World, a rotating skyscraper, and a beach designed by Versace, complete with chilled sand have been delayed. However after six years of quick expansion, the emirate had approximately $600 billion going into construction and is home to the worlds tallest building, the worlds largest shopping mall,  the biggest man-made island and  an indoor ski resort. These rapid developments caused a 7% increase in population anually. WILSON, Z (2009) However, once the recession hit the country, the economic conditions and development scuttled. Currently, an estimated 50% of construction have been delayed or cancelled, banks have stopped lending, real estate prices fell down by 41% in the first quarter of 2009 and are estimated to drop more and the stock market has fallen 70% from its peak. Due to this economic crisis, the expatriates living in the emirate are either fleeing or have lost their jobs. When the economy of Dubai was in its booming stage, it had 80% of its total 1.7 million residents to be foreigners. As long as this economic condition prevails in the emirate, life is going to be a challenge for the foreigners and other residents. However Abu Dhabi which is the capital of U.A.E has helped Dubai with $10 billion which is still a small amount when compared to the debt of Dubai estimated to be over $50 billion. Abu Dhabi is also being affected slowly due to the recession. However the impact is lesser than Dubai since Abu Dhabi controls over 90% of U.A.Es oil reserve and is also home to one among the biggest investment company in the world known as ADIA (Abu Dhabi Investment Authority) The research will have its focus mainly on the damage done to the financial market and Business of the country. U.A.Es strategy towards gaining momentum in overcoming the economic crisis will be critically analyzed. Personal reasons: U.A.Es development has always amused me. The country is one among the leading business hubs with all major multinational companies in the world. I had always wanted to study the business sector and financial market of U.A.E but coming from an Engineering background I did not have the tools and resources to do so which is the reason I have taken MSc International Business. I am taking this opportunity to study the countrys business using the tools and resources that I have already studied and going to study during my course. Moreover it would help me to understand more about International Business and reasons to the economic downfall of U.A.E. This would also help me once I go back in order to start a business. The knowledge of the economic situation and its detailed study would help me a great deal. III.PRELIMINARY LITERATURE REVIEW: During the late 2007, with the US economy going through its worst post war recession, the global economy faced the most synchronised recession ever which was a result of increased globalisation and global interdependence financially and trade linkages. The economies of almost all the major developed countries shrivelled rapidly along with many trade dependent developing countries which include U.A.E along with other major countries like India and China. Anirvan B and Pami D (2010). Before the spread of the global recession, it was believed only the U.S economy will face the economic downfall. But almost the whole of Europe and cuntries like India and China were also hit badly along with U.A.E which is a small developing country with big ambition. The economy of dubai was growing at an alarming rate with projects estimated to approximately $660 billion until the recession hit. In november 2009, the announcement of Dubai that it was going to freeze $26 billion of debt was a shock to the world and after two months when the real estate market crashed, Dubai government had over $60 billion debt which created serious doubts in the minds of investors about Dubai. A political science professor at Durham University in the U.K. stated The real story of Dubai is that it was a trick, Christopher D (2010). Abu Dhabi which is the capital of United Arab Emirates has been using its $43 billion of annual oil revenue to work controlled by one among the worlds biggest investment company called ADIA (Abu Dhabi Investment Authority) building art museums, mosques and a renewable energy research institute. Pendleton and Devon (2010) Vol.  185 Issue 5, p108-109 With the likes of abundant oil reserves of Abu Dhabi and one of the worlds biggest institutional investors (ADIA), Dubai has a ray of hope in surviving the current economic crisis. Abu Dhabi Inbestment Authority is known to be one of the biggest financial institutions in the world ranking second after the Bank of Japan, according to the Oxford Business Group. Roy and Sudip ()2006, Vol.  37 (444), 70-76. The company established in 1976 by the late ruler of U.A.E Sheikh Zayed Bin Sultan Al Nahiyan had its gaol towards investing the countrys surpluses in International market with low risks. The company currently manages U.A.Es surplus oil reserve which is estimated to be approximately $500 billion. The company has been able to raise its liquidity during this global crisis when equity market was struck severely. The country is mainly depending on the turnover of this establishment. The companys aproach towards investment in US and Europe market are looking strong. Sheikh Ahmad say s US treasuries are still the most liquid benchmark bonds in the world and will remain an important diversification tool. Mccrum and Philip (2010), Vol.  54 ,8, p30-31. In 2009, Dubais Jebel Ali airport which is going to be the worlds biggest airport found its construction at halt as its development plans were threatened by the gloabl economic crisis. The current economic situation has mainly affected the real estate market of U.A.E. With reduced net migration, decreasing jobs and the lack of availbility of credit has badly affected the real estate market. The prices for properties has gone down by 40% and reduced liquidity and credit for developers has shut down major projects. While there is no consumption data, inflation figures are below requirements. Dubais à ¢Ã¢â€š ¬Ã‹Å"housing, electricity, gas and other fuels inflation was at 0.5% in February 2009 which was the lowest during that year. Emerging Markets Monitor (2010) 16,(32) 17. The emirate of Abu Dhabi shows less vulnerability to the current economic crisis when compared to Dubai. The Dubai Government had announces at 6 month stand still for debt payments in november 2009. U.A.Es economic recovery only started gaining momentum in 2010. In this research, I will endeavour to highlight the key positive development that has occured since the recession and critically analyze the countrys future strategy. IV.RESEARCH questions and OBJECTIVES: 4.1 Research QUESTIONS: What are the reasons for the tragic economic downfall of U.A.E especially in the emirate of Dubai? What is the extent of damage to the financial market and business in the country due to the recession? How badly is the real estate market sector affected due to recession and what are its impacts on the residents? How has this economic downfall affected the countrys financial market? What are the measures undertaken by the government and private business sectors to recover from the financial crisis? 4.2 Research OBJECTIVES: To critically analyze the reason for the economic downfall in U.A.E. To critically analyze and comment on the extent of damage and the precise business sectors that are most affected due to the recession in U.A.E. To critically evaluate the downfall in the real estate market and its impact on the residents To evaluate the effect of recession on U.A.Es financial market. Finally, to comment on the measures undertaken to recover from the financial crisis and recommend measures which can help the recovery V.RESEARCH PLAN: Analysing a global phenomenon (the green phenomenon) at a European level and carrying out researches about a pillar industry (the automotive industry) that indicates most of the European countries economic health implies that various data are available. Whilst numerous advantages such as giving precious in-depth data concerning the topic, it also means that important drawbacks will arise such as so-called fake or disinformation data. Furthermore, this fact also implies that while collecting accurate data on such hot topics, the need to constantly access the latest and up to date data will be crucial and even unavoidable alongside my research. 5. 1 Data collection methods outline 5.1.1 Secondary Data In order to complete my research, I will be using secondary data like text books that are available at Coventry University related to Business strategy and Management to use the appropriate tools required to analyze a company or business that is hostile due to recession. Books like Business strategy Formulation Ulwick, Anthony W (2004), Chaotics: The Business of Managing and Marketing in the Age of Turbulence  Kotler, Philip  Ãƒâ€šÃ‚  Ãƒâ€šÃ‚  C, John A (2009) and Stock Market Cycles: Practical Explanation Bolten, Steven E.  Ãƒâ€šÃ‚  (2000). Other databases like EBSCO will be used to find journals and articles related to my research area. Articles like à ¢Ã¢â€š ¬Ã‹Å"Jebel Ali terminal faces 12-month delay Foreman,c (2009) Middle East Economic digest, Vol 3,(9) 18 and à ¢Ã¢â€š ¬Ã‹Å"Contractors pay for falling prices Foreman,c (2009) Middle East Economic digest, Vol 53,(5) 27-30.. Other articles and journals will be used for as my research progresses. Database li ke SAGE journals will also be used to find journals on Global recession and its effect on develpoed and developing countries. 5.1.2 Primary data Interviews One on one interview will be conducted with the IT department head of ADIA (Abu Dhabi investment Authority) as a part of primary data collection for my research. The interview will help me understand and perceive how the company is doing and regarding their current investments. Depending on the quality and depth of the information collected from this interview, I will be conducting another interview with the Marketing Manager of Abu Dhabi Cable Factory L.L.C which is a company I used to work for before the start of my course at Coventry University. All these data will help me comment on the present economic condition in United Arab Emirates and their future plans as my research progresses. 5.2 Data collection methods per objective In order to complete my first objective, I will be using journals and articles from databases like EBSCO and SAGE journals that contains materials purely on recession, its roots and forecasts. The second objective will be addressed using the information collected from the interviews and journals from EBSCO. For the third objective, information will be collected from databases like EBSO and SAGE journals. Additional information will be collected from local newspaper articles in United Arab Emirates. For the fourth and the fifth objective, information collected from the interviews will be used along with other journals and articles. In order to recommend measures which could help the recovery from recession, I would use information from books like Business strategy Formulation Ulwick, Anthony W (2004), Chaotics: The Business of Managing and Marketing in the Age of Turbulence  Kotler, Philip  Ãƒâ€šÃ‚  Ãƒâ€šÃ‚  C, John A (2009). 5.3 Analysis of data Primary data collected by interview will be grouped accordingly to answer the necessary objective of my research work. In order to do so I will be using the NVIVO 9 software which will help me analyze any unstructured information collected. 5.4 Limitations As far as the secondary data is concerned, the limitations are that the information available is from a third persons point of view which might not be accurate and also that we could find information contradicting some particular information since the research will talk about issues concerning the reason for the countrys current economic condition and measures that could be employed to overcome the economic crisis. The limitations for the primary data would be that the information collected may not be precise as it is information regarding a company or economy from an individuals perspective. VI.ETHICS I will ensure that I will follow the Universitys ethical procedures and submit the low risk ethical approval form and follow all the guidelines. For my primary data collection, I shall use the participation information leaflet for interviews and also attach a consent form for interviews. Interviews will not be conducted in ways that could go against the ethical issues like harm the respondents or question their honesty. All the data collected will be treated confidentially and will not be used for any other purpose than the research work. All data will be securely kept in line with the Data Protection Act 1998. VII.LIST OF REFERENCES Wilson, Z (2009) ROAD TO NOWHERE  : FAST COMPANY 138, (13) 90-93 BusinessWeek (2009) ECONOMICS POLICY JAWBONING THE BANKS  4161, (4) 8-13 available at http://web.ebscohost.com/ehost/detail?hid=15sid=67e26db4-aa56-4136-9b5e-63151b0d62e8%40sessionmgr14vid=10bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#db=bthAN=47040807 Foreman, C (2009) Jebel Ali terminal faces 12-month delay : MEED-  Middle East Economic Digest 53, (9) 18 Anirvan, B and Pami, D (2010) Synchronisation of Recessions in Major Developed and Emerging Economie  : The Journal of Applied Economic Research 4, (2) 197-223 avalible at http://mar.sagepub.com/content/4/2/197.full.pdf+html Pendleton and Devon (2010) Middle Eastern Mirage  : Forbes 185, (5) 108-109 Mccrum and Philip (2010) Abu Dhabi begins to open up.  : MEED-  Middle East Economic Digest 54, (8) 30-31 Ulwick and Anthony, W (2004) Business strategy Formulation Kotler  ; Philip, C and John A (2009) Chaotics: The Business of Managing and Marketing in the Age of Turbulence   Bolten and Steven, E.  Ãƒâ€šÃ‚  (2000) Stock Market Cycles: Practical Explanation Middle East Monitor:  The Gulf (2010) 20, (5) 4-5 avalilable at http://content.ebscohost.com/pdf23_24/pdf/2010/D9B/01May10/49018531.pdf?T=PP=ANK=49018531S=RD=bthEbscoContent=dGJyMNHr7ESeqLE4yNfsOLCmr0mep7VSs6u4Sq%2BWxWXSContentCustomer=dGJyMPGvtk%2BwrrFQuePfgeyx44Dt6fIA Emerging Markets Monitor (2010) Vol.  16 Issue 32, p17-17 available at http://content.ebscohost.com/pdf25_26/pdf/2010/5DB/22Nov10/55340054.pdf?T=PP=ANK=55340054S=RD=bthEbscoContent=dGJyMNHr7ESeqLE4yNfsOLCmr0mep7VSsKi4Sa6WxWXSContentCustomer=dGJyMPGvtk%2BwrrFQuePfgeyx44Dt6fIA Analysis of Causes of UAE Economic Downfall Analysis of Causes of UAE Economic Downfall Introduction and Business reasons: The global liquidity crunch has affected most of the countries and among the highly affected countries is United Arab Emirates which was one among the growing business hubs in the world with its massive development and acceptance of different culture and business. Dubai known as the economic capital of U.A.E was badly affected by the recession. Consequently, huge fortunes have been wiped out due to Dubais current economic crisis exposing the risk of doing business in the Gulf. The expansion of Dubai was very ambitious but improbable. A $64 billion project that was initially planned at 107 square miles for a development that was to be the worlds largest collection of theme parks, shops, residences, and hotels called the Dubai Land.  For now all these remain a fantasy which is the cause of the economic downturn. WILSON, Z (2009) As a consequence to that, various other projects like an underwater hotel, a Tiger Woods golf course, a residential community set among full-scale replicas of the Seven Wonders of the World, a rotating skyscraper, and a beach designed by Versace, complete with chilled sand have been delayed. However after six years of quick expansion, the emirate had approximately $600 billion going into construction and is home to the worlds tallest building, the worlds largest shopping mall,  the biggest man-made island and  an indoor ski resort. These rapid developments caused a 7% increase in population anually. WILSON, Z (2009) However, once the recession hit the country, the economic conditions and development scuttled. Currently, an estimated 50% of construction have been delayed or cancelled, banks have stopped lending, real estate prices fell down by 41% in the first quarter of 2009 and are estimated to drop more and the stock market has fallen 70% from its peak. Due to this economic crisis, the expatriates living in the emirate are either fleeing or have lost their jobs. When the economy of Dubai was in its booming stage, it had 80% of its total 1.7 million residents to be foreigners. As long as this economic condition prevails in the emirate, life is going to be a challenge for the foreigners and other residents. However Abu Dhabi which is the capital of U.A.E has helped Dubai with $10 billion which is still a small amount when compared to the debt of Dubai estimated to be over $50 billion. Abu Dhabi is also being affected slowly due to the recession. However the impact is lesser than Dubai since Abu Dhabi controls over 90% of U.A.Es oil reserve and is also home to one among the biggest investment company in the world known as ADIA (Abu Dhabi Investment Authority) The research will have its focus mainly on the damage done to the financial market and Business of the country. U.A.Es strategy towards gaining momentum in overcoming the economic crisis will be critically analyzed. Personal reasons: U.A.Es development has always amused me. The country is one among the leading business hubs with all major multinational companies in the world. I had always wanted to study the business sector and financial market of U.A.E but coming from an Engineering background I did not have the tools and resources to do so which is the reason I have taken MSc International Business. I am taking this opportunity to study the countrys business using the tools and resources that I have already studied and going to study during my course. Moreover it would help me to understand more about International Business and reasons to the economic downfall of U.A.E. This would also help me once I go back in order to start a business. The knowledge of the economic situation and its detailed study would help me a great deal. III.PRELIMINARY LITERATURE REVIEW: During the late 2007, with the US economy going through its worst post war recession, the global economy faced the most synchronised recession ever which was a result of increased globalisation and global interdependence financially and trade linkages. The economies of almost all the major developed countries shrivelled rapidly along with many trade dependent developing countries which include U.A.E along with other major countries like India and China. Anirvan B and Pami D (2010). Before the spread of the global recession, it was believed only the U.S economy will face the economic downfall. But almost the whole of Europe and cuntries like India and China were also hit badly along with U.A.E which is a small developing country with big ambition. The economy of dubai was growing at an alarming rate with projects estimated to approximately $660 billion until the recession hit. In november 2009, the announcement of Dubai that it was going to freeze $26 billion of debt was a shock to the world and after two months when the real estate market crashed, Dubai government had over $60 billion debt which created serious doubts in the minds of investors about Dubai. A political science professor at Durham University in the U.K. stated The real story of Dubai is that it was a trick, Christopher D (2010). Abu Dhabi which is the capital of United Arab Emirates has been using its $43 billion of annual oil revenue to work controlled by one among the worlds biggest investment company called ADIA (Abu Dhabi Investment Authority) building art museums, mosques and a renewable energy research institute. Pendleton and Devon (2010) Vol.  185 Issue 5, p108-109 With the likes of abundant oil reserves of Abu Dhabi and one of the worlds biggest institutional investors (ADIA), Dubai has a ray of hope in surviving the current economic crisis. Abu Dhabi Inbestment Authority is known to be one of the biggest financial institutions in the world ranking second after the Bank of Japan, according to the Oxford Business Group. Roy and Sudip ()2006, Vol.  37 (444), 70-76. The company established in 1976 by the late ruler of U.A.E Sheikh Zayed Bin Sultan Al Nahiyan had its gaol towards investing the countrys surpluses in International market with low risks. The company currently manages U.A.Es surplus oil reserve which is estimated to be approximately $500 billion. The company has been able to raise its liquidity during this global crisis when equity market was struck severely. The country is mainly depending on the turnover of this establishment. The companys aproach towards investment in US and Europe market are looking strong. Sheikh Ahmad say s US treasuries are still the most liquid benchmark bonds in the world and will remain an important diversification tool. Mccrum and Philip (2010), Vol.  54 ,8, p30-31. In 2009, Dubais Jebel Ali airport which is going to be the worlds biggest airport found its construction at halt as its development plans were threatened by the gloabl economic crisis. The current economic situation has mainly affected the real estate market of U.A.E. With reduced net migration, decreasing jobs and the lack of availbility of credit has badly affected the real estate market. The prices for properties has gone down by 40% and reduced liquidity and credit for developers has shut down major projects. While there is no consumption data, inflation figures are below requirements. Dubais à ¢Ã¢â€š ¬Ã‹Å"housing, electricity, gas and other fuels inflation was at 0.5% in February 2009 which was the lowest during that year. Emerging Markets Monitor (2010) 16,(32) 17. The emirate of Abu Dhabi shows less vulnerability to the current economic crisis when compared to Dubai. The Dubai Government had announces at 6 month stand still for debt payments in november 2009. U.A.Es economic recovery only started gaining momentum in 2010. In this research, I will endeavour to highlight the key positive development that has occured since the recession and critically analyze the countrys future strategy. IV.RESEARCH questions and OBJECTIVES: 4.1 Research QUESTIONS: What are the reasons for the tragic economic downfall of U.A.E especially in the emirate of Dubai? What is the extent of damage to the financial market and business in the country due to the recession? How badly is the real estate market sector affected due to recession and what are its impacts on the residents? How has this economic downfall affected the countrys financial market? What are the measures undertaken by the government and private business sectors to recover from the financial crisis? 4.2 Research OBJECTIVES: To critically analyze the reason for the economic downfall in U.A.E. To critically analyze and comment on the extent of damage and the precise business sectors that are most affected due to the recession in U.A.E. To critically evaluate the downfall in the real estate market and its impact on the residents To evaluate the effect of recession on U.A.Es financial market. Finally, to comment on the measures undertaken to recover from the financial crisis and recommend measures which can help the recovery V.RESEARCH PLAN: Analysing a global phenomenon (the green phenomenon) at a European level and carrying out researches about a pillar industry (the automotive industry) that indicates most of the European countries economic health implies that various data are available. Whilst numerous advantages such as giving precious in-depth data concerning the topic, it also means that important drawbacks will arise such as so-called fake or disinformation data. Furthermore, this fact also implies that while collecting accurate data on such hot topics, the need to constantly access the latest and up to date data will be crucial and even unavoidable alongside my research. 5. 1 Data collection methods outline 5.1.1 Secondary Data In order to complete my research, I will be using secondary data like text books that are available at Coventry University related to Business strategy and Management to use the appropriate tools required to analyze a company or business that is hostile due to recession. Books like Business strategy Formulation Ulwick, Anthony W (2004), Chaotics: The Business of Managing and Marketing in the Age of Turbulence  Kotler, Philip  Ãƒâ€šÃ‚  Ãƒâ€šÃ‚  C, John A (2009) and Stock Market Cycles: Practical Explanation Bolten, Steven E.  Ãƒâ€šÃ‚  (2000). Other databases like EBSCO will be used to find journals and articles related to my research area. Articles like à ¢Ã¢â€š ¬Ã‹Å"Jebel Ali terminal faces 12-month delay Foreman,c (2009) Middle East Economic digest, Vol 3,(9) 18 and à ¢Ã¢â€š ¬Ã‹Å"Contractors pay for falling prices Foreman,c (2009) Middle East Economic digest, Vol 53,(5) 27-30.. Other articles and journals will be used for as my research progresses. Database li ke SAGE journals will also be used to find journals on Global recession and its effect on develpoed and developing countries. 5.1.2 Primary data Interviews One on one interview will be conducted with the IT department head of ADIA (Abu Dhabi investment Authority) as a part of primary data collection for my research. The interview will help me understand and perceive how the company is doing and regarding their current investments. Depending on the quality and depth of the information collected from this interview, I will be conducting another interview with the Marketing Manager of Abu Dhabi Cable Factory L.L.C which is a company I used to work for before the start of my course at Coventry University. All these data will help me comment on the present economic condition in United Arab Emirates and their future plans as my research progresses. 5.2 Data collection methods per objective In order to complete my first objective, I will be using journals and articles from databases like EBSCO and SAGE journals that contains materials purely on recession, its roots and forecasts. The second objective will be addressed using the information collected from the interviews and journals from EBSCO. For the third objective, information will be collected from databases like EBSO and SAGE journals. Additional information will be collected from local newspaper articles in United Arab Emirates. For the fourth and the fifth objective, information collected from the interviews will be used along with other journals and articles. In order to recommend measures which could help the recovery from recession, I would use information from books like Business strategy Formulation Ulwick, Anthony W (2004), Chaotics: The Business of Managing and Marketing in the Age of Turbulence  Kotler, Philip  Ãƒâ€šÃ‚  Ãƒâ€šÃ‚  C, John A (2009). 5.3 Analysis of data Primary data collected by interview will be grouped accordingly to answer the necessary objective of my research work. In order to do so I will be using the NVIVO 9 software which will help me analyze any unstructured information collected. 5.4 Limitations As far as the secondary data is concerned, the limitations are that the information available is from a third persons point of view which might not be accurate and also that we could find information contradicting some particular information since the research will talk about issues concerning the reason for the countrys current economic condition and measures that could be employed to overcome the economic crisis. The limitations for the primary data would be that the information collected may not be precise as it is information regarding a company or economy from an individuals perspective. VI.ETHICS I will ensure that I will follow the Universitys ethical procedures and submit the low risk ethical approval form and follow all the guidelines. For my primary data collection, I shall use the participation information leaflet for interviews and also attach a consent form for interviews. Interviews will not be conducted in ways that could go against the ethical issues like harm the respondents or question their honesty. All the data collected will be treated confidentially and will not be used for any other purpose than the research work. All data will be securely kept in line with the Data Protection Act 1998. VII.LIST OF REFERENCES Wilson, Z (2009) ROAD TO NOWHERE  : FAST COMPANY 138, (13) 90-93 BusinessWeek (2009) ECONOMICS POLICY JAWBONING THE BANKS  4161, (4) 8-13 available at http://web.ebscohost.com/ehost/detail?hid=15sid=67e26db4-aa56-4136-9b5e-63151b0d62e8%40sessionmgr14vid=10bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#db=bthAN=47040807 Foreman, C (2009) Jebel Ali terminal faces 12-month delay : MEED-  Middle East Economic Digest 53, (9) 18 Anirvan, B and Pami, D (2010) Synchronisation of Recessions in Major Developed and Emerging Economie  : The Journal of Applied Economic Research 4, (2) 197-223 avalible at http://mar.sagepub.com/content/4/2/197.full.pdf+html Pendleton and Devon (2010) Middle Eastern Mirage  : Forbes 185, (5) 108-109 Mccrum and Philip (2010) Abu Dhabi begins to open up.  : MEED-  Middle East Economic Digest 54, (8) 30-31 Ulwick and Anthony, W (2004) Business strategy Formulation Kotler  ; Philip, C and John A (2009) Chaotics: The Business of Managing and Marketing in the Age of Turbulence   Bolten and Steven, E.  Ãƒâ€šÃ‚  (2000) Stock Market Cycles: Practical Explanation Middle East Monitor:  The Gulf (2010) 20, (5) 4-5 avalilable at http://content.ebscohost.com/pdf23_24/pdf/2010/D9B/01May10/49018531.pdf?T=PP=ANK=49018531S=RD=bthEbscoContent=dGJyMNHr7ESeqLE4yNfsOLCmr0mep7VSs6u4Sq%2BWxWXSContentCustomer=dGJyMPGvtk%2BwrrFQuePfgeyx44Dt6fIA Emerging Markets Monitor (2010) Vol.  16 Issue 32, p17-17 available at http://content.ebscohost.com/pdf25_26/pdf/2010/5DB/22Nov10/55340054.pdf?T=PP=ANK=55340054S=RD=bthEbscoContent=dGJyMNHr7ESeqLE4yNfsOLCmr0mep7VSsKi4Sa6WxWXSContentCustomer=dGJyMPGvtk%2BwrrFQuePfgeyx44Dt6fIA

The Pathophysiology of Hepatitis B Essay -- Health, Diseases

Introduction Hepatitis B, an infectious disease caused by the Hepatitis B virus (HBV, a DNA virus), was formerly called serum hepatitis, inoculation hepatitis and post-transfusion hepatitis. Infection with HBV may result in acute, fulminant or chronic hepatitis, sometimes even resulting in a chronic asymptomatic carrier state, apart from hepatocellular carcinoma and liver cirrhosis (Davis 179). The disease is transmitted when an individual comes in contact with infected blood or objects. It may also be transferred from an infected mother to her infant either during or after birth (Zuckerman et al. 211). Transmission may also occur by accidental inoculation from infected needles and hospital equipment, intravenous drug abuse, body piercing, tattooing, and mouth-mouth kissing (Zuckerman et al. 210). The risk of Hepatitis B is particularly high in individuals with multiple sex partners, and in homosexuals. The HBV virus occurs in morphologically different forms in the serum of infected individuals. HBV infection has an incubation period of about 75 days. Systemic symptoms of the disease include fatigue, fever, dyspepsia, arthralgia, malaise, and rash, while local symptoms include hepatomegaly, jaundice, dark urine, and pale stools (Davis 179; Zuckerman et al. 210). Anatomical/physiological/biochemical changes that lead to the disease Hepatitis B results from cellular injury to the liver, subsequently affecting its metabolic functions. However, the HBV is not cytopathic by itself. The pathogenesis of Hepatitis B occurs as a result of the interactions between the host’s immune system and the virus. The host immune system targets HBV in liver cells (hepatocytes), inadvertently causing damage to the liver. HBV derived proteins (... ...BeAg), bilirubin level, and platelet count (Pyrsopoulos and Reddy). The disease prognosis can be done by calculating the prognostic index based on the status of these six variables. Conclusion HBV infection is complex and affects a large population worldwide. The discovery of the Australia antigen (HBsAg) in 1965 by Blumberg et al. (1965) set the stage for rapid progress in understanding and counteracting the disease (qtd in Zuckerman et al. 210). Liver function tests help in estimating the extent of damage caused to the liver during HBV infection. Diagnosis is done by detecting viral specific antigens in the serum. Both active and passive immunization options exist for disease prophylaxis. However, it is always best to practice caution over the parenteral, sexual and other routes of transmission of the disease for effective disease prevention and prophylaxis.

Justice And Injustice Essay -- essays research papers

In The Republic, the great philosopher Plato attempts to reveal through the character and dialogues of Socrates that justice is better when it is the good for which men must strive for, regardless of whether they could be unjust and still be rewarded. His method is to use dialectic, the asking and answering of questions. This method leads the audience from one point to another, supposedly with indisputable logic by obtaining agreement to each point before going on to the next, therefore, building an argument.   Ã‚  Ã‚  Ã‚  Ã‚  Interestingly about the work of Socrates is that its not known very well, since nothing was recorded during his time. Everything that we know about Socrates has come through the writings of his greatest pupil, Plato. Socrates was a man that revolutionized philosophy and how to approach his surroundings. One of Socrates greatest findings as a philosopher was that he admitted that he knew nothing, which to others, specifically the Delphic Oracle led them to believe that there were none wiser than Socrates. Socrates techniques as a philosopher came about with his abilities to question others. His line of questioning, to see why everything had a purpose drew a crowd of younger people, which leads us to The Republic, where Socrates encounters some questions for him.   Ã‚  Ã‚  Ã‚  Ã‚  Socrates had two young listeners posing questions of whether justice is stronger than injustice, and what each does to a man? What makes the first good and the second bad? In answering this question, Socrates deals directly with the philosophy of the individual's goodness and virtue, but also binds it to his concept of the perfect state, which is a republic of three classes of people with a rigid social structure and little in the way of amusement.   Ã‚  Ã‚  Ã‚  Ã‚  Although Socrates reiterates the concept of justice over and over again it all comes to his discourse on the perfect city-state, which seems a bit off the mark, considering his original subject. However, one of Socrates’ main points is that goodness is doing what is best for the common. It is greater good as opposed to that of individual happiness. There is a real sense in which his philosophy turns on the concepts of virtue, and his belief that ultimately virtue is its own reward. His first major point is that justice is an excellence of character. He then se... ...uite compassionate. Since happiness is the sign of justice, and pleasure is one sign of happiness, then the just person is the happy person. Socrates then equates true pleasure with knowledge, the province of reason and the philosopher.   Ã‚  Ã‚  Ã‚  Ã‚   Within Book X, In The Republic, Socrates argues for the existence of an immortal soul. With this plead, he makes the point that good is that which preserves and benefits. Justice is good, so it therefore preserves and benefits in this life as well as the next. Therefore, even though a man may wish to behave badly when no one is looking, as with the myth of the ring of Gyges, according to Socrates, by behaving justly we will have the most rewards. Eventually, the difficulty with Socrates' arguments is that they rely on associating things on to the next in a chain that eventually leads back to the original proposition. But, the logic of these connections seems built more on assumptions than on objective truth. Thus, within keeping his stance that ultimately what he says is right is right because he is a philosopher, and therefore is by his nature right. The dialectic seems more of a game to get the audience to go along.

Company Introduction, Market Segmentation, and Product Positioning Essay

The key to successful product implementation in today’s national enterprise system is the effective marketing of a new product with the company’s line of existing products. As stated by Lacobucci (2012), marketing is defined as an exchange between a company and its customers. The customer wants something from the company or firm and vice versa. In previous times, a company would manufacture a product they thought the customer would want or need. The customer purchased that product because of a pending need, which basically meant that marketing used to be product oriented. However, marketing today is more that an advertisement for goods and services in an attempt to attract new business. We live in a customer orientated and empowered marketing environment. We realize the importance and ramifications of having an exchange with our customers and developing a relationship with them. It is this exchange of information between our company and our existing as well as future customers that secures our position in our target market. Our company is a regional tool distributor located in the northeastern section of the United States. Our customer base consists of several major retailers, nationally known in the retail and wholesale tool industry. We used the brand label Blue Steel Tools for marketing and distribution of our products to discuss the implementation of an effective plan to market a new product line, the Illuminated Power Wrench. This paper will analyze market, identify our market segment for sales distribution and discuss the reasoning for the segment. Discussing the target market and why the targeted customers were specifically selected. We will do the SWOT analysis; describe the unique market position and the expected service provided in meeting the needs of the target audience. 1. Identify the marketing segment for the product and provide a rationale for this segment. The definition of a market segment as stated by Lacobucci (2012) is a group of customers that shares similar inclinations towards our brand. To define market segment further for our needs, it is an identifiable group of individuals, professionals or organizations that share one or more characteristics or needs in an otherwise homogenous market. In our case, our product will have a very wide market of consumers and small business owners and employees. Therefore we will need to reduce the market segments to larger chunks. Market segments generally respond in a predictable manner to a marketing or promotion offer. The market segment for the new product will vary widely due to the versatility of our product usage. Our main segment approach will focus on the wholesale distribution to retail repair supply stores who carry lines of tools for resale to the private and business consumer. These market segments will include businesses such as Lowes and Home Depot, retail tool distributors such as Harbor Freight Tools, automobile parts stores such as Advance Auto Parts and tool catalogue companies such as great Northern to name a few. As we analyze this segment we ask the question if this segment is viable and can we profit from using it. Other considerations are accessibility and measurability. This segment is small enough to manage our sales and distribution, but large enough to reach the ultimate user of our product. This market segment possesses the potential and versatility to sell and distribute our product to the target consumer market with a widely diversified audience in the retail industry. The bases for this segmentation include similar demographics, geographical locations, and psychological make-up of customers and behaviors of users/purchasers. In other words, the customer base for our segments meets the desired user of our end product. Anyone who builds or repairs something whether they are a novice or professional is a potential customer. Therefore, by using this method of market segmentation for product distribution, we will successfully sub-divide a large homogenous market into clear identifiable and manageable segments that have similar needs, wants or demand characteristics indicated by Lacobucci (2012). 2. Discuss the target market and provide rationale for this target market. The target market defined is the particular market segment at which a marketing campaign is focused. As stated earlier, this product has been designed for the retail tool industry. We have targeted segments in the industry that will be the most successful in reaching the consumer and generating a demand for our product through steady sales. Lacobucci stated the first perspective in assessing segments target is to have a view of the segments themselves and the primary concern is the segment be profitable. This in turn will become a profitability issue for our company as we continue to hold a place in the small tool market and generate profits with continued sales. The second perspective examined was if the market or segment fit with who we are. In this case the answer is yes. The ultimate target for this product is the consumer. The greater exposure we have, the higher propensity for sales growth. The illuminated ratchet screw driver is a quality tool for use by not only the novice home self repair person; it will also meet the needs of the professional repair person, no matter what the industry. The illumination system in the handle of the wrench will appeal to the vehicle mechanic working in the close quarters of an engine compartment, the electrician repairing the circuit breaker box, the computer repair technician working in between electronic circuitry as well as to the basic consumer performing handy maintenance projects. This tool will come with the standard wrench lugs and have availability to accessories such as wrench tips to enhance its versatility to meet the needs of a wider target audience. The wider target audience is customers of our targeted market segments. Therefore the target market is our pathway to the ultimate user of the product is consumer sales. The strategic sales objective of these retail establishments coincides with our strategic vision of reaching the ultimate user of our products, satisfying their needs and increasing the likelihood of additional product sales. 3. Perform a SWOT (strengths, weakness, opportunities and treats) for the company. As we move forward in the marketing of our product, we need to our own corporate strengths. Lacobucci (2012) suggests the use of a SWOT analysis in identifying our strengths, weaknesses, opportunities and threats. The strengths and weaknesses characterize our company in relation to competitors where the opportunities and threats characterize the broader environment such as the tool industry, suppliers, the government and etc. Our strengths are in our track record in t he tool industry. We have provided quality products at competitive prices. Another perceived strength is in the management of our company. The senior management of Steel City Tools has provided a strategic vision with clearly defined attainable goals for market position and sales. However a perceived threat is in the foreign market. A number of tool company’s efforts have been over shadowed with a cheaper duplication of products from foreign markets. The US has been plagued with a reduction in the manufacturing industry due to globalized markets, elimination of trade barriers and outsourcing. The end result is our market segment (distributor) could purchase a similar product cheaper and increase their gross margin and not purchase our product for resale. Another threat we are not prepared to react to is loss of a major distributing customer. With more and more businesses merging, we could lose a distribution source with no warning. One of our weaknesses is we have focused on sales east of the Mississippi, thus limiting market expansion. However, this could be turned around as a future opportunity for market expansion. An easy way to expand our market is to establish a retail division and use infomercials through the cable television network to accept mail order/telephone order select product sales such as our new illuminated power wrench. However, a marketing effort of this nature would require careful consideration must be given to the geographical area so as not to alienate our primary segment customers. A move of this nature would require additional capital investment and careful analysis of this type of expansion would be necessary to minimize risk of project failure. The SWOT is useful in clarifying our marketing questions. The key is to address our shortcomings so as not to give the competition an upper hand and not raise concerns with our customers and capitalize on our strengths for continued success. 4. Create the market position for your product and service. Explain your rationale. Product positioning, according to the Encyclopedia of Business, involves the tailoring the entire marketing program to include product features, distribution, price, quality and service to meet the needs of the consumer within the specific market segment. In this manner, the product positioning is part of the overall market segmentation. Product position takes place in our distributors store, or target market segment and tells us how we can strive most effectively in that market segment against our competition which are also present on display. The key is to understand the consumer perceptions of the product and the marketing behind it. Quality, reliability, affordability, unique features, benefits to the customer is just a few attributes of product positioning. According to Lacobucci (2012) positioning is often about modifying the four P’s of marketing (position, price, place and promotion). In the case of our company, our reputation is a reflection of the position to provide a quality product at a competitive price while leading the market in innovation. Our company performance is attributed to the quality of our employment staff. Our employees are at the core to our success. We have established core values for our company’s work force by creating a positive work culture with recognition of the whole person concept. The strategic leadership from the top on down to the employee fosters productivity with reward and recognition to enhance their performance in support of the company operations to include our marketing efforts. Thus the positive and proactive personality of our company in meeting its marketing objectives is a direct reflection of the quality of every member of the Blue Steel Tool Team. As we continue to grow and develop products for sale, we position our products at a distribution sales point or market segment with the greatest customer exposure for maximum market penetration. We will service our product to the satisfaction and benefit of the customer so as not to jeopardize customer confidence as well as the business relationship with our market segment. The product we create and the service we provide are a direct reflection of not only our company, but that of our distributors. Our products are designed to meet the working needs of our professional as well as consumer clientele with a level of quality that meet or exceed expectations at the best value. References Lacobucci, D. (2012) Marketing Management: 2012 custom edition. Mason OH Market Segment Defined Retrieved from http://www. businessdictionary. com/definition/market-segment. html Morley R. (2006), Trumpet Print Edition: The Death of American Manufacturing, February 2006 Retrieved from http://www. thetrumpet. com/index. php? page=article&id=1955 Reference for Business Product Positioning: Encyclopedia of Business, 2nd ed. Retrieved from http://www. referenceforbusiness. com/small/Op-Qu/Product-Positioning. html Target Market Defined retrieved from http://www. businessdictionary. com/definition/target-market. html

Ethos Outline Essay

When you write you must believe that people will wonder and question your authority. g. Maybe not scientific expertise, but personal experience. . Having profession titles also can endorse trust. i. Small signals of authority can be picked up almost subconsciously IV. Establishing Credibility j. Humor puts a listener at ease, and helps them identify k. Listen to people confident enough to make fun of themselves. l. Move quickly to reasonable claims after and back it up with evidence. m. Audiences respond to how you present yourself as a person. n. Using language to show that you respect, not talking about nor below them. o. Citing respectable sources to show that you have done your work. p. Using conditions of rebuttal. V. Coming Clean about Motives q. Readers will ask how it benefits the narrator of the idea. r. Stating blanking how, and potential conflicts of interest will cause gained trust. s. In political circles, it is almost sport to assume the worst about motives. t. Admission of uncertainty helps build a bridge. After reading about the appeal of Ethos I mostly reflected on the fact that there was a lot I had never thought about with natural human tendencies. Mostly what was interesting to me was the fact that we mostly base our trust on the character of a person. Maybe if they back up their statements with facts we will believe, but it all starts with the character of a person. I also had never thought that people started with humor because they needed to connect, and bring themselves to a trusting level with their audience. Another thing I had not thought of was that readers will always question their writers, even subconsciously, about many different subjects. One main point I did not understand completely was talking about motives, and how saying conflicts of interest would help you connect to your reader, besides just on a trust level. Besides that I thought this chapter was very interesting, and contained many things that made sense, but I had never thought about or questioned before.

Signal Transduction Exam 2018

This figure is from Labasque et al., 2008 (GPCR week). A) Describe the experiment shown here and what was learned as a result. B) Design a negative control for this experiment and describe why it is a good control. C) Design an experiment to confirm this result in living cells. Please include controls in your experimental design. Signal Transduction Exam 2018 A) The experiment was performed on human embryonic kidney (HEK 293) cell line. The extracts of solubilized proteins were taken under consideration for this experiment. These were then transfected with different vectors: CTL (empty vectors), co-transfected with GFP fused Calmodulin(GFP-CaM) and serotonin receptor either wild type 5-HT2C or 5-HT2CR376/377A which were treated with a vehicle or 5-HT for five minutes, they analyzed the binding reaction by Western Blot and Immunoprecipitation (IP) techniques. Immunoprecipitation was done of these soluble proteins with polyclonal antibody:anti-GFP. Furthermore, these immunoprecipitated proteins were blotted using a monoclonal anti-GFP antibody along with anti-5-HT2C receptor antibody.As a result of this experiment, it was found that the absence of agonist, 5-HT2C receptor did not co-immunoprecipitate with calmodulin in solubilized proteins that were co-transfected with Myc-5-HT2C receptor and GFP-CaM. However, serotonin receptor co-immunoprecipitated with GFP-CaM after treatment with 5-HT for 5 minutes. But the exposure with 5-HT2CR376/377A did not co-immunoprecipitate GFP-CaM with serotonin receptor. It proves that 5-HT2C receptors are linked with CaM depending on the presence of agonist. The experiment performed is to check the agonist dependent precipitation of GFP-CaM and serotonin receptors in the presence of Myc-5HT2C 5-HT exposure. So, the negative control to be designed here for this experiment can be simply of serotonin receptor and CaM. This would result in no immunoprecipitation and prove as a good negative control. On analyzing it through western blotting it could be proved that no immunoprecipitation had occurred in this control. To confirm the results in living cells the same experiment could be used to check the that whether the immunoprecipitation is agonist dependent or not. Take solubilized proteins from living cells and co-transfect them with GFP-CaM and 5-HT2C receptor followed by exposure to 5-HT, then analyze immunoprecipitation via western blotting. The negative control for this experiment will include only CaM and serotonin receptor, and further analyzing it with western blotting, the results of blotting will show no precipitation in negative.2. These figures are from Fig. 6A,C of Fan et al. (src kinase folder). (A) Explain the experiments shown here. What was being tested? What conclusions can be drawn? How can it be improved? (B) Design another experiment to test the same concept/hypothesis? Include your controls.4839335107886500A) In figure A: Human embryonic kidney cells were transfected with constructs for carrying out this experiment. Immuno-precipitation was carried out of tagged PAG with an antibody against regulator MYC, its interaction is studied here with SRC and BRK followed by immunoblotting analyzation. The result of this experiment was delaying in electrophoretic mobility of tagged PAG protein, when it was co-expressed with SRC. This delay is considered due to the hyper-phosphorylation. However, on co-expression of PAG and BRK this band shift was less evident. In figure C: Co-transfection of HEK 293 cells with MYC-PAG and SRC followed by treatment in the absence or presence of SRC kinase inhibitor SU6656 (5 M) for at least 1 hour. PAG was immunoprecipitated by antibody against MYC, and the binding of CSK was compared by immunoblotting. On the other hand, the disturbance of link b/w CSK and PAG was observed on weakening SRC activity by a small molecular inhibitor SU6656, this experiment concluded the importance of SRC kinase activity for functioning of CSK. Also, this study shows that distinct mechanisms have evolved to regulate the activities of two structurally similar and functionally related kinases, BRK and SRC, understanding of the signaling function of protein phosphatases, including definition of their substrate specificities, will allow us to exploit a greater spectrum of the changes in signaling in disease and to generate new and more effective strategies for therapeutic intervention in major human diseasesB) To test the same hypothesis with controls, take breast cancer frozen samples of different patients, divide the sample in two groups one will be the test group other the control group. The control group will be given doses of anti-tumor medication (like tamoxifen for breast cancer). RNA will be extracted from both groups using Trizol and will be followed by purification assay. The breast cancer cell lines will be transfected with empty vectors or pcDNA3-MKP3-V5. Furthermore, the transfectants will be placed in media like minimum essential media MEM with phenol red, followed by SDS PAGE electrophoresis, and transfer to nitrocellulose membrane. After transferring they will be incubated with primary antibody for an hour or more then with the secondary antibody to observe the chemiluminescence with a reagent. The cells will then be lysed in a buffer, phosphatase reaction carried out will be observed by assays and transfected cells will be compared with control ones to whom tamoxifen was given.36734750003. This is figure 4b from Gresset et al (phospholipases folder). (A) What is the hypothesis being tested in this experiment? (B) Describe how the experiment was done, including results. (C) Predict what might happen to PLC? activity if Tyrosine783 was ‘permanently' phosphorylated and explain why. The hypothesis being tested here is the enhancement in the lipase activity of phospholipaseC-?1 via phosphorylation of one or both specified tyrosine residues (Y775 and Y783) in the downstream process of signal transduction.To perform the experiment, equal concentrations of purified phospholipase-C-?1 were set on incubation with the active kinase domain of the Fibroblast growth factor receptor FGFR2 and ATP in bovine serum albumin containing buffer, the samples of this reactions were tested for two activities: 1) for lipase activity in the phospholipid vehicles indicated in the figure on left Y axis. Secondly the phosphate incorporation in phospholipase-C-?1 was studied, illustrated at right Y axis of the figure. 4 moles of phosphate were added to each test samples, the Wildtype inactive PLC?1 was taken as a normal control with its basal phospholipase activity, active PLC?1 with wildtype FGFR2K served as a positive control with phosphate and PLC?1 knockout mutant served as negative control to quantify the phospholipase activity among the mutants. This was performed to check the phosphorylation of tyrosine and auto inhibition of PLC-? isozymes, 775/783 of PLC-?1 were substitutes at the place of phenylalanine, they could be used individually or together, but in the experiment tyr783 is used individually. Phospholipase activity of resulting mutant after purification was quantified with active domain of FGFR2K (helps in phosphorylation and activation of phospholipase). Certain known moles of phosphates were added into purified PLC-?1 in wild type under above mentioned conditions and observed that phospholipase activity was enhanced 10 times. The mutation of tyr783 completely nullified the kinase stimulated acceleration of phospholipase activity along with reduction in FGFR2K-promoted phosphorylation of PLC-?1. This experiment proves that, phosphorylation of Tyr783 is vital for relief of auto-inhibition.Studies reveal that Tyr-783 was essential for auto inhibition. As discussed above, permanent phosphorylation of tyr-783 will completely nullify the kinase stimulated and FGFR2K stimulated phosphorylation of PLC-?1. Lipase activity of PLC-?1 will be enhanced across its limits and over-expression of PLC-?1 can induce malignant transformation. The results could be leading to production of carcinoma cells. It has been found in various studies that activity of PLC-?1 is more in cancerous cells as compared to normal cells. So, permanent phosphorylation tyr783 could be a way leading to malignant cancers.3416300-254000004. This figure is from Tsui et al. 2015. (lipid raft folder). (A) Explain the relationship between GFR and Ret51 and what they are testing in this paper (the overall idea). (B) Explain the experiment shown in this figure and what was learned. (C) What is a negative control that could improve the conclusions from this experiment?GFR and Ret51 both are receptors, GDNF is found to promote PNS development and kidney morphogenesis through the receptor complex consisting of GDNF family receptor 1 (GFR1) and the other receptor tyrosine kinase (Ret). Ret signal transduction is increased by translocation of GFR. GFR-mediated Ret activation is essential too for the kidney morphogenesis and for various other functions of abdominal precursors that form abdominal nervous system. Also, GFR has many lipid rafts because its GPI anchorage, but Ret is expelled from lipid rafts. In this paper, the gene replacement for GFR in mice results GDNF resulting in Ret activation but prevented its translocation into lipid rafts. These mice showed renal agenesis, and other disorders including loss of the enteric nervous system, and defects in motor neuron axon path similar to GFR mice that was knocked out, all this provided evidence along with lipid rafts GFR is also needed for neurotrophic factor signaling.Primary considerate neurons secluded from Gfr1and Gfr1TM/TM mice were maintained in vitro for some days. Then they treated the neurons with GDNF or medium for exact time of 15 minutes. The Detergent-resistant membranes quarantined from the neurons were examined by immunoblotting for Ret51. The comparative purity of detergent resistant and detergent soluble fractions was confirmed by using immunoblotting for caveolin and transferrin receptor, respectively B, the experiments shown in A, were computed and graphed. Otherwise, Substantial decline in the amount of Ret51 was recorded statistically that translocated into lipid rafts while GDNF stimulation in Gfr1TM/TM neurons compared with Gfr1 neurons. Similar Results were obtained after performing the experiment four times .Moreover, Lipid raft translocation experiments were performed to prove the concept that GDNF/GFR1/Ret complex does not translocate into lipid rafts in Gfr1TM/TM mice. Primary sympathetic neurons from Gfr1/ and Gfr1TM/TM mice were used to extract detergent-resistant membranes. Upon stimulation of Gfr1/ neurons with GDNF, Ret translocated quickly into lipid rafts. This was a contrast to Gfr1TM/TM neurons that an evident reduced movement of Ret into the detergent-resistant was recorded because of GDNF exposure. A small portion of Ret that did translocate into lipid rafts while stimulation may be owing to Ret kinase-dependent translocation of Ret into rafts that occurs with slower movements. There was a significant, 75% reduction in the kinetics of the Ret receptor complex into lipid rafts during GDNF exposure in Gfr1TM/TM neurons according to computation made by these experiments. The negative control design here for confirming the results that Ret doesn't translocate into lipid rafts during GFL activation in Gfr1TM/TM neurons, the primary sympathetic neurons isolated from Gfr1/and Gfr1TM/TM mice will be grown in the same way as test ones, with the only difference that there will be no treatment with GDNF or medium for 15 minutes, and the impact of this will confirm the result to much greater extent upon immunoblotting.